Acute and chronic cardiovascular effects of pentolinium in hypertensive patients

Using a tracer injection technic, modified to provide accurate and repeated determinations of cardiac output in the ambulatory patient, the authors have shown that chronic pentolinium therapy for hypertension lowers blood pressure by reducing cardiac output in the seated position. From these observations and the work of others, they believe that the effect of ganglionic blockade on venoconstrictor tone deserves greater emphasis.