The bovine spleen: Interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections
Over the past several years, innate immunity has been recognized as having an important role as a front-line defense mechanism and as an integral part of the adaptive immune response. Innate immunity in cattle exposed to hemoparasites is spleen-dependent and age-related. In this review, we discuss g...
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Veröffentlicht in: | Veterinary immunology and immunopathology 2010-11, Vol.138 (1), p.1-14 |
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creator | Goff, W.L. Bastos, R.G. Brown, W.C. Johnson, W.C. Schneider, D.A. |
description | Over the past several years, innate immunity has been recognized as having an important role as a front-line defense mechanism and as an integral part of the adaptive immune response. Innate immunity in cattle exposed to hemoparasites is spleen-dependent and age-related. In this review, we discuss general aspects of innate immunity and the cells involved in this aspect of the response to infection. We also provide examples of specific splenic regulatory and effector mechanisms involved in the response to
Babesia bovis, an important tick-borne hemoparasitic disease of cattle. Evidence for the regulatory and effector role of bovine splenic monocytes and DC both in directing a type-1 response through interaction with splenic NK cells and γδT-cells will be presented. |
doi_str_mv | 10.1016/j.vetimm.2010.07.006 |
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Babesia bovis, an important tick-borne hemoparasitic disease of cattle. Evidence for the regulatory and effector role of bovine splenic monocytes and DC both in directing a type-1 response through interaction with splenic NK cells and γδT-cells will be presented.</description><identifier>ISSN: 0165-2427</identifier><identifier>EISSN: 1873-2534</identifier><identifier>DOI: 10.1016/j.vetimm.2010.07.006</identifier><identifier>PMID: 20692048</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Babesia ; Babesia bovis ; Babesiosis - immunology ; cattle ; Cattle - genetics ; Cattle - immunology ; cattle diseases ; Cattle Diseases - genetics ; Cattle Diseases - immunology ; cytokines ; Cytokines - biosynthesis ; Cytokines - genetics ; Dendritic Cells - immunology ; gene expression regulation ; immune response ; immunity ; Immunity, Innate ; Innate immunity ; interferons ; Killer Cells, Natural - immunology ; literature reviews ; Models, Immunological ; Myeloid Cells - immunology ; natural killer cells ; nitric oxide ; Nitric Oxide - biosynthesis ; NK cells ; Parasitemia - genetics ; Parasitemia - immunology ; Parasitemia - veterinary ; protozoal infections ; RNA, Messenger - genetics ; Spleen ; Spleen - cytology ; Spleen - immunology ; splenocytes ; T-Lymphocyte Subsets - immunology ; T-lymphocytes ; γδT cells</subject><ispartof>Veterinary immunology and immunopathology, 2010-11, Vol.138 (1), p.1-14</ispartof><rights>2010</rights><rights>Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-4b81e959a0b94ae23b8c7056ad999d1e66cfefb96fb7036f6c753cdb88dc47023</citedby><cites>FETCH-LOGICAL-c417t-4b81e959a0b94ae23b8c7056ad999d1e66cfefb96fb7036f6c753cdb88dc47023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165242710002436$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20692048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goff, W.L.</creatorcontrib><creatorcontrib>Bastos, R.G.</creatorcontrib><creatorcontrib>Brown, W.C.</creatorcontrib><creatorcontrib>Johnson, W.C.</creatorcontrib><creatorcontrib>Schneider, D.A.</creatorcontrib><title>The bovine spleen: Interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections</title><title>Veterinary immunology and immunopathology</title><addtitle>Vet Immunol Immunopathol</addtitle><description>Over the past several years, innate immunity has been recognized as having an important role as a front-line defense mechanism and as an integral part of the adaptive immune response. Innate immunity in cattle exposed to hemoparasites is spleen-dependent and age-related. In this review, we discuss general aspects of innate immunity and the cells involved in this aspect of the response to infection. We also provide examples of specific splenic regulatory and effector mechanisms involved in the response to
Babesia bovis, an important tick-borne hemoparasitic disease of cattle. Evidence for the regulatory and effector role of bovine splenic monocytes and DC both in directing a type-1 response through interaction with splenic NK cells and γδT-cells will be presented.</description><subject>Animals</subject><subject>Babesia</subject><subject>Babesia bovis</subject><subject>Babesiosis - immunology</subject><subject>cattle</subject><subject>Cattle - genetics</subject><subject>Cattle - immunology</subject><subject>cattle diseases</subject><subject>Cattle Diseases - genetics</subject><subject>Cattle Diseases - immunology</subject><subject>cytokines</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - genetics</subject><subject>Dendritic Cells - immunology</subject><subject>gene expression regulation</subject><subject>immune response</subject><subject>immunity</subject><subject>Immunity, Innate</subject><subject>Innate immunity</subject><subject>interferons</subject><subject>Killer Cells, Natural - immunology</subject><subject>literature reviews</subject><subject>Models, Immunological</subject><subject>Myeloid Cells - immunology</subject><subject>natural killer cells</subject><subject>nitric oxide</subject><subject>Nitric Oxide - biosynthesis</subject><subject>NK cells</subject><subject>Parasitemia - genetics</subject><subject>Parasitemia - immunology</subject><subject>Parasitemia - veterinary</subject><subject>protozoal infections</subject><subject>RNA, Messenger - genetics</subject><subject>Spleen</subject><subject>Spleen - cytology</subject><subject>Spleen - immunology</subject><subject>splenocytes</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-lymphocytes</subject><subject>γδT cells</subject><issn>0165-2427</issn><issn>1873-2534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EokvhHyDIjVOWceL4gwMSqvioVIkD7dlynMnWq8QOtrMSEj8eLykc4TTSvM-8Y89LyEsKewqUvz3uT5jdPO8bKC0QewD-iOyoFG3ddC17THYF6-qGNeKCPEvpCACdkvIpuWiAqwaY3JGft_dY9eHkPFZpmRD9u-raZ4zGZhd8qswc_OG35J2tLE5TtYRlncwmO1_l4uC8N7mUeV59mMLhjAafY5iqMFb3OIfFRJNcLoLzI27mz8mT0UwJXzzUS3L36ePt1Zf65uvn66sPN7VlVOSa9ZKi6pSBXjGDTdtLK6DjZlBKDRQ5tyOOveJjL6DlI7eia-3QSzlYJqBpL8mbzXeJ4fuKKevZpfNXjMewJi2p4KAa1f2XFJ1gnFEQhWQbaWNIKeKol-hmE39oCvockD7qLSB9DkiD0CWgMvbqYcHazzj8HfqTSAFeb8BogjaH6JK--1YcWqBSCSFUId5vBJaTnRxGnaxDb3FwsRxWD8H9-w2_AN-Nr84</recordid><startdate>20101115</startdate><enddate>20101115</enddate><creator>Goff, W.L.</creator><creator>Bastos, R.G.</creator><creator>Brown, W.C.</creator><creator>Johnson, W.C.</creator><creator>Schneider, D.A.</creator><general>Elsevier B.V</general><general>Amsterdam: Elsevier</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20101115</creationdate><title>The bovine spleen: Interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections</title><author>Goff, W.L. ; Bastos, R.G. ; Brown, W.C. ; Johnson, W.C. ; Schneider, D.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-4b81e959a0b94ae23b8c7056ad999d1e66cfefb96fb7036f6c753cdb88dc47023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Babesia</topic><topic>Babesia bovis</topic><topic>Babesiosis - immunology</topic><topic>cattle</topic><topic>Cattle - genetics</topic><topic>Cattle - immunology</topic><topic>cattle diseases</topic><topic>Cattle Diseases - genetics</topic><topic>Cattle Diseases - immunology</topic><topic>cytokines</topic><topic>Cytokines - biosynthesis</topic><topic>Cytokines - genetics</topic><topic>Dendritic Cells - immunology</topic><topic>gene expression regulation</topic><topic>immune response</topic><topic>immunity</topic><topic>Immunity, Innate</topic><topic>Innate immunity</topic><topic>interferons</topic><topic>Killer Cells, Natural - immunology</topic><topic>literature reviews</topic><topic>Models, Immunological</topic><topic>Myeloid Cells - immunology</topic><topic>natural killer cells</topic><topic>nitric oxide</topic><topic>Nitric Oxide - biosynthesis</topic><topic>NK cells</topic><topic>Parasitemia - genetics</topic><topic>Parasitemia - immunology</topic><topic>Parasitemia - veterinary</topic><topic>protozoal infections</topic><topic>RNA, Messenger - genetics</topic><topic>Spleen</topic><topic>Spleen - cytology</topic><topic>Spleen - immunology</topic><topic>splenocytes</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-lymphocytes</topic><topic>γδT cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goff, W.L.</creatorcontrib><creatorcontrib>Bastos, R.G.</creatorcontrib><creatorcontrib>Brown, W.C.</creatorcontrib><creatorcontrib>Johnson, W.C.</creatorcontrib><creatorcontrib>Schneider, D.A.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Veterinary immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goff, W.L.</au><au>Bastos, R.G.</au><au>Brown, W.C.</au><au>Johnson, W.C.</au><au>Schneider, D.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The bovine spleen: Interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections</atitle><jtitle>Veterinary immunology and immunopathology</jtitle><addtitle>Vet Immunol Immunopathol</addtitle><date>2010-11-15</date><risdate>2010</risdate><volume>138</volume><issue>1</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>0165-2427</issn><eissn>1873-2534</eissn><abstract>Over the past several years, innate immunity has been recognized as having an important role as a front-line defense mechanism and as an integral part of the adaptive immune response. Innate immunity in cattle exposed to hemoparasites is spleen-dependent and age-related. In this review, we discuss general aspects of innate immunity and the cells involved in this aspect of the response to infection. We also provide examples of specific splenic regulatory and effector mechanisms involved in the response to
Babesia bovis, an important tick-borne hemoparasitic disease of cattle. Evidence for the regulatory and effector role of bovine splenic monocytes and DC both in directing a type-1 response through interaction with splenic NK cells and γδT-cells will be presented.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>20692048</pmid><doi>10.1016/j.vetimm.2010.07.006</doi><tpages>14</tpages></addata></record> |
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subjects | Animals Babesia Babesia bovis Babesiosis - immunology cattle Cattle - genetics Cattle - immunology cattle diseases Cattle Diseases - genetics Cattle Diseases - immunology cytokines Cytokines - biosynthesis Cytokines - genetics Dendritic Cells - immunology gene expression regulation immune response immunity Immunity, Innate Innate immunity interferons Killer Cells, Natural - immunology literature reviews Models, Immunological Myeloid Cells - immunology natural killer cells nitric oxide Nitric Oxide - biosynthesis NK cells Parasitemia - genetics Parasitemia - immunology Parasitemia - veterinary protozoal infections RNA, Messenger - genetics Spleen Spleen - cytology Spleen - immunology splenocytes T-Lymphocyte Subsets - immunology T-lymphocytes γδT cells |
title | The bovine spleen: Interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections |
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