The bovine spleen: Interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections

Over the past several years, innate immunity has been recognized as having an important role as a front-line defense mechanism and as an integral part of the adaptive immune response. Innate immunity in cattle exposed to hemoparasites is spleen-dependent and age-related. In this review, we discuss g...

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Veröffentlicht in:Veterinary immunology and immunopathology 2010-11, Vol.138 (1), p.1-14
Hauptverfasser: Goff, W.L., Bastos, R.G., Brown, W.C., Johnson, W.C., Schneider, D.A.
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container_issue 1
container_start_page 1
container_title Veterinary immunology and immunopathology
container_volume 138
creator Goff, W.L.
Bastos, R.G.
Brown, W.C.
Johnson, W.C.
Schneider, D.A.
description Over the past several years, innate immunity has been recognized as having an important role as a front-line defense mechanism and as an integral part of the adaptive immune response. Innate immunity in cattle exposed to hemoparasites is spleen-dependent and age-related. In this review, we discuss general aspects of innate immunity and the cells involved in this aspect of the response to infection. We also provide examples of specific splenic regulatory and effector mechanisms involved in the response to Babesia bovis, an important tick-borne hemoparasitic disease of cattle. Evidence for the regulatory and effector role of bovine splenic monocytes and DC both in directing a type-1 response through interaction with splenic NK cells and γδT-cells will be presented.
doi_str_mv 10.1016/j.vetimm.2010.07.006
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Animals
Babesia
Babesia bovis
Babesiosis - immunology
cattle
Cattle - genetics
Cattle - immunology
cattle diseases
Cattle Diseases - genetics
Cattle Diseases - immunology
cytokines
Cytokines - biosynthesis
Cytokines - genetics
Dendritic Cells - immunology
gene expression regulation
immune response
immunity
Immunity, Innate
Innate immunity
interferons
Killer Cells, Natural - immunology
literature reviews
Models, Immunological
Myeloid Cells - immunology
natural killer cells
nitric oxide
Nitric Oxide - biosynthesis
NK cells
Parasitemia - genetics
Parasitemia - immunology
Parasitemia - veterinary
protozoal infections
RNA, Messenger - genetics
Spleen
Spleen - cytology
Spleen - immunology
splenocytes
T-Lymphocyte Subsets - immunology
T-lymphocytes
γδT cells
title The bovine spleen: Interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections
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