The pathogenesis of MALT lymphomas: where do we stand?

Mucosa-associated lymphoid tissue (MALT) lymphoma is a heterogeneous form of a B-cell non-Hodgkin's lymphoma with extranodal location. The gastrointestinal tract is the most common site of disease, but involvement of multiple other organ systems has been documented. Four translocations, t(11;18...

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Veröffentlicht in:	Leukemia 2007-03, Vol.21 (3), p.389-396
Hauptverfasser:	Sagaert, X, De Wolf-Peeters, C, Noels, H, Baens, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens, Bacterial - immunology Autoantigens - immunology B-Lymphocyte Subsets - immunology Biological and medical sciences Cancer Research Caspases - genetics Caspases - physiology Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 1 - ultrastructure Chromosomes, Human, Pair 11 - genetics Chromosomes, Human, Pair 11 - ultrastructure Chromosomes, Human, Pair 14 - genetics Chromosomes, Human, Pair 14 - ultrastructure Chromosomes, Human, Pair 18 - genetics Chromosomes, Human, Pair 18 - ultrastructure Chronic Disease Control Critical Care Medicine Development and progression Disease Gastritis - complications Gastritis - drug therapy Gastritis - immunology Gastritis - microbiology Gastrointestinal Neoplasms - etiology Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - microbiology Gastrointestinal system Gastrointestinal tract Gene Expression Regulation, Neoplastic Genes Genes, Immunoglobulin Genotoxicity Helicobacter Infections - complications Helicobacter Infections - drug therapy Helicobacter Infections - immunology Helicobacter pylori - immunology Hematologic and hematopoietic diseases Hematology Humans Immunoglobulin Heavy Chains - genetics Infections Inflammation - complications Intensive Internal Medicine Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphocytes B Lymphoma Lymphoma, B-Cell, Marginal Zone - drug therapy Lymphoma, B-Cell, Marginal Zone - etiology Lymphoma, B-Cell, Marginal Zone - genetics Lymphoma, B-Cell, Marginal Zone - immunology Lymphoma, B-Cell, Marginal Zone - microbiology MALT lymphoma Medical sciences Medicine Medicine & Public Health Mice Mice, Transgenic Morphology Mucosa Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein Mucosal-associated lymphoid tissue Mutation Neoplasm Proteins - genetics Neoplasm Proteins - physiology NF-kappa B - physiology NF-κB protein Non-Hodgkin's lymphoma Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - physiology Oncology Pathogenesis review Risk factors Thyroid gland Translocation Translocation, Genetic Tumorigenesis
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Zusammenfassung:	Mucosa-associated lymphoid tissue (MALT) lymphoma is a heterogeneous form of a B-cell non-Hodgkin's lymphoma with extranodal location. The gastrointestinal tract is the most common site of disease, but involvement of multiple other organ systems has been documented. Four translocations, t(11;18)(q21;q21), t(1;14)(p22;q32), t(14;18)(q32;q21) and t(3;14)(p13;q32), are specifically associated with MALT lymphoma. Remarkably, the genes targeted by at least three of these translocations are involved in one and the same pathway, leading to the activation of nuclear factor- κ B (NF- κ B). This review presents MALT lymphoma as a model of how sustained inflammation increases the risk of genotoxic insults and how these genetic events initiate oncogenesis.
ISSN:	0887-6924 1476-5551
DOI:	10.1038/sj.leu.2404517