Mid-trimester hypertonic saline-induced abortion: Effect of indomethacin on induction/abortion time

Mid-trimester hypertonic saline-induced abortion: Effect of indomethacin on induction/abortion time

The oral administration of indomethacin to patients undergoing hypertonic saline-induced mid-trimester abortion prolonged significantly (p < 0.001) the induction/abortion time interval when compared to control patients receiving no medication. Since prostaglandins are intimately associated with t...

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Veröffentlicht in:American journal of obstetrics and gynecology 1972-11, Vol.114 (6), p.829-831
Hauptverfasser: Waltman, Richard, Tricomi, Vincent, Palav, Aravind B.
Format: Artikel
Sprache:eng
Schlagworte:
Abortion, Induced
Female
Gestational Age
Humans
Hypertonic Solutions
Indomethacin - pharmacology
Pregnancy
Prostaglandin Antagonists
Sodium Chloride
Time Factors
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Zusammenfassung:The oral administration of indomethacin to patients undergoing hypertonic saline-induced mid-trimester abortion prolonged significantly (p < 0.001) the induction/abortion time interval when compared to control patients receiving no medication. Since prostaglandins are intimately associated with the abortion and birth processes and nonsteroidal anti-inflammatory aspirin-like drugs suppress prostaglandin biosynthesis, the mechanism by which hypertonic saline-induced abortion occurs is suggested.
ISSN:0002-9378
1097-6868
DOI:10.1016/0002-9378(72)90910-6