Alkaline Phosphatase Activity and Diet

Alkaline phosphatase activity of rat liver has been found to be sensitive to variation in the proportion of casein and dextrose in the diet. Activity values were found to be high not only when there was a large proportion of dextrose but also when there was a large proportion of casein in the diet. Low activity values were found when these dietary constituents were present in approximately equal proportions. Alkaline phosphatase activity was found to be directly affected by variation in the casein content when the dextrose content was held constant and by variation in the dextrose content when the casein content was held constant. A variation in the amount or in the proportion of the dietary factors, casein and dextrose, has been shown to alter the alkaline phosphatase activity.