Comparison of Effect of ‘Valmid’∗ and Other Hypnotics on Brain Respiration in vitro

Comparison of Effect of ‘Valmid’∗ and Other Hypnotics on Brain Respiration in vitro

Summary ‘Valmid’, a new nonbarbituric hypnotic, has been compared with ‘Seconal Sodium’, urethane, and a convulsant barbiturate with respect to its ability to inhibit normal and potassium-stimulated respiration of rat brain cortex slices in vitro. In concentrations equivalent to those obtained durin...

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Veröffentlicht in:Experimental biology and medicine (Maywood, N.J.) N.J.), 1956-08, Vol.92 (4), p.778-780
Hauptverfasser: Tust, Ralmond H., Herrmann, Roy G., Chen, K. K.
Format: Artikel
Sprache:eng
Schlagworte:
Brain - drug effects
Carbamates
Cell Respiration
Humans
Hypnotics and Sedatives - pharmacology
In Vitro Techniques
Old Medline
Respiration
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Zusammenfassung:Summary ‘Valmid’, a new nonbarbituric hypnotic, has been compared with ‘Seconal Sodium’, urethane, and a convulsant barbiturate with respect to its ability to inhibit normal and potassium-stimulated respiration of rat brain cortex slices in vitro. In concentrations equivalent to those obtained during anesthesia, only ‘Seconal Sodium’ depressed the oxygen uptake of normal tissue whereas both ‘Seconal Sodium’ and ‘Valmid’ inhibited the respiration of KCl-stimulated tissue.
ISSN:0037-9727
1535-3702
1535-3699
DOI:10.3181/00379727-92-22611