Mechanism of Acetylaminofluorene-dG Induced Frameshifting by Polymerase η

Frameshift mutations: Bulky adduct DNA lesions, such as the C8‐acetylaminofluorene dG lesion (AAF‐dG), induce frameshift mutations if they are placed in special gene sequences. With the help of synthetic AAF‐dG lesions inserted into different repetitive frameshift‐prone sequences, the molecular basi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2010-12, Vol.11 (18), p.2534-2537
Hauptverfasser:	Schorr, Stephanie, Carell, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Acetylaminofluorene - analogs & derivatives 2-Acetylaminofluorene - metabolism acetylaminofluorene Base Sequence bulky adducts Cloning, Molecular Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism DNA - genetics DNA - metabolism DNA Damage DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Escherichia coli - genetics Frameshift Mutation frameshift mutations polymerase chain reaction Saccharomyces cerevisiae - enzymology Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Frameshift mutations: Bulky adduct DNA lesions, such as the C8‐acetylaminofluorene dG lesion (AAF‐dG), induce frameshift mutations if they are placed in special gene sequences. With the help of synthetic AAF‐dG lesions inserted into different repetitive frameshift‐prone sequences, the molecular basis of the −I, −II, and −III frameshifting events was determined.
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201000579