Protein surface recognition using geometrically pure Ru(II) tris(bipyridine) derivatives

Protein surface recognition using geometrically pure Ru(II) tris(bipyridine) derivatives

This manuscript illustrates that the geometric arrangement of protein-binding groups around a ruthenium(II) core leads to dramatic differences in cytochrome c (cyt c) binding highlighting that it is possible to define synthetic receptors with shape complementarity to protein surfaces.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2011-01, Vol.47 (1), p.559-561
Hauptverfasser: Filby, Maria H, Muldoon, James, Dabb, Serin, Fletcher, Nicholas C, Ashcroft, Alison E, Wilson, Andrew J
Format: Artikel
Sprache:eng
Schlagworte:
2,2'-Dipyridyl - analogs & derivatives
2,2'-Dipyridyl - chemistry
Binding Sites
Cytochromes c - chemistry
Cytochromes c - metabolism
Models, Molecular
Molecular Structure
Surface Properties
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Beschreibung
Zusammenfassung:This manuscript illustrates that the geometric arrangement of protein-binding groups around a ruthenium(II) core leads to dramatic differences in cytochrome c (cyt c) binding highlighting that it is possible to define synthetic receptors with shape complementarity to protein surfaces.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc04754f