Peroxiredoxin 2 as a chemotherapy responsiveness biomarker candidate in osteosarcoma revealed by proteomics

Purpose: We aimed to identify novel chemotherapy responsiveness biomarkers for osteosarcoma (OS) by investigating the global protein expression profile of 12 biopsy samples from OS patients. Experimental design: Six patients were classified as good responders and six as poor responders, according to...

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Veröffentlicht in:	Proteomics. Clinical applications 2010-05, Vol.4 (5), p.560-567
Hauptverfasser:	Kikuta, Kazutaka, Tochigi, Naobumi, Saito, Shigeru, Shimoda, Tadakazu, Morioka, Hideo, Toyama, Yoshiaki, Hosono, Ako, Suehara, Yoshiyuki, Beppu, Yasuo, Kawai, Akira, Hirohashi, Setsuo, Kondo, Tadashi
Format:	Artikel
Sprache:	eng
Schlagworte:	2-D DIGE Adolescent Adult Biological and medical sciences Biomarkers, Tumor - metabolism Bone Neoplasms - drug therapy Bone Neoplasms - metabolism Chemotherapy Child Diseases of the osteoarticular system Diverse techniques Female Fundamental and applied biological sciences. Psychology Gene Expression Profiling Humans Male Medical sciences Molecular and cellular biology Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - metabolism Peroxiredoxin 2 Peroxiredoxins - metabolism Prognosis Proteomics - methods Tumors of striated muscle and skeleton
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Zusammenfassung:	Purpose: We aimed to identify novel chemotherapy responsiveness biomarkers for osteosarcoma (OS) by investigating the global protein expression profile of 12 biopsy samples from OS patients. Experimental design: Six patients were classified as good responders and six as poor responders, according to the Huvos grading system. The protein expression profiles obtained by 2‐D DIGE consisted of 2250 protein spots. Results: Among them, we identified 55 protein spots whose intensity was significantly different (Bonferroni adjusted p‐value
ISSN:	1862-8346 1862-8354
DOI:	10.1002/prca.200900172