Proteomic analysis of breast cancer tissue reveals upregulation of actin‐remodeling proteins and its relevance to cancer invasiveness

Proteomic analysis of breast cancer tissue reveals upregulation of actin‐remodeling proteins and its relevance to cancer invasiveness

There is an emerging interest in protein expression profiling with the aim of identifying novel diagnostic markers and therapeutic targets in breast cancer. We analyzed breast cancer tissues by 2‐D DIGE using a narrow range IPG strip (pH 5.5–6.7) after the immunodepletion of serum albumin and Ig. Si...

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Veröffentlicht in:Proteomics. Clinical applications 2009-01, Vol.3 (1), p.30-40
Hauptverfasser: Kim, Dong‐Hyun, Bae, Jinhee, Lee, Jong Won, Kim, Seon‐Young, Kim, Yong‐Hak, Bae, Ji‐Yeon, Yi, Jae Kyo, Yu, Myeong‐Hee, Noh, Dong‐Young, Lee, Cheolju
Format: Artikel
Sprache:eng
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Arp2/3 complex subunit 2
Breast cancer
Coronin‐1A
DIGE
Invasion assay
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Zusammenfassung:There is an emerging interest in protein expression profiling with the aim of identifying novel diagnostic markers and therapeutic targets in breast cancer. We analyzed breast cancer tissues by 2‐D DIGE using a narrow range IPG strip (pH 5.5–6.7) after the immunodepletion of serum albumin and Ig. Sixty‐three protein spots were detected with more than ±1.8‐fold differences (p 
ISSN:1862-8346
1862-8354
DOI:10.1002/prca.200800167