Interaction between warfarin and Korean red ginseng in patients with cardiac valve replacement

Abstract Background The objective of this study was to determine whether an interaction exists between warfarin and Korean red ginseng. Methods A prospective, double-blind, randomized, two-period crossover study was conducted on 25 patients with cardiac valve replacement under warfarin therapy. Eith...

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Veröffentlicht in:International journal of cardiology 2010-11, Vol.145 (2), p.275-276
Hauptverfasser: Lee, Yeon Hong, Lee, Byung Koo, Choi, Yoon Jung, Yoon, In Kyung, Chang, Byung Chul, Gwak, Hye Sun
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Sprache:eng
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Zusammenfassung:Abstract Background The objective of this study was to determine whether an interaction exists between warfarin and Korean red ginseng. Methods A prospective, double-blind, randomized, two-period crossover study was conducted on 25 patients with cardiac valve replacement under warfarin therapy. Either Korean red ginseng 1 g or placebo (hop extract 0.25 g, caramel color 0.05 g, and red ginseng flavor 0.03 g) was concomitantly administered with warfarin. INR and warfarin concentrations were analyzed on the 3rd and 6th weeks of each study period. Results The INR changes on the 3rd and 6th weeks of Korean red ginseng administration were − 0.16 ± 0.95 and − 0.14 ± 0.94 whereas those of placebo were − 0.03 ± 0.65 and 0.25 ± 0.95; there were no statistically significant differences in mean INR changes. Conclusion Korean red ginseng could be used with close monitoring and under appropriate education in patients who take warfarin.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2009.09.553