Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis

Summary Background Long-term statin treatment reduces the frequency of cardiovascular events, but safety and efficacy in patients with abnormal liver tests is unclear. We assessed whether statin therapy is safe and effective for these patients through post-hoc analysis of the Greek Atorvastatin and...

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Veröffentlicht in:	The Lancet (British edition) 2010-12, Vol.376 (9756), p.1916-1922
Hauptverfasser:	Athyros, Vasilios G, MD, Tziomalos, Konstantinos, MD, Gossios, Thomas D, MD, Griva, Theodora, MD, Anagnostis, Panagiotis, MD, Kargiotis, Konstantinos, MD, Pagourelias, Efstathios D, MD, Theocharidou, Eleni, MD, Karagiannis, Asterios, Prof, Mikhailidis, Dimitri P, Dr
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Atherosclerosis Biological and medical sciences Cardiology. Vascular system Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - drug therapy Coronary Disease - complications Coronary Disease - drug therapy Coronary heart disease Data collection Diabetes Fatty Liver - blood Fatty Liver - complications Fatty Liver - drug therapy Female General aspects Greece Heart Heart failure Hospitals Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Insulin resistance Internal Medicine Liver Liver Function Tests Male Medical sciences Middle Aged Mortality Non-alcoholic Fatty Liver Disease Prospective Studies Recurrence Regression analysis Risk Reduction Behavior Statins Time Factors Treatment Outcome
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Zusammenfassung:	Summary Background Long-term statin treatment reduces the frequency of cardiovascular events, but safety and efficacy in patients with abnormal liver tests is unclear. We assessed whether statin therapy is safe and effective for these patients through post-hoc analysis of the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) study population. Methods GREACE was a prospective, intention-to-treat study that randomly assigned by a computer-generated randomisation list 1600 patients with coronary heart disease (aged 2·6 mmol/L and triglycerides
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(10)61272-X