Diagnosis of fetal maturity by amniotic fluid phospholipids

Diagnosis of fetal maturity by amniotic fluid phospholipids

A lecithin/sphingomyelin (L/S) ratio of >1.75 indicates pulmonary maturity. With the use of thin-layer chromatography, the L/S ratio can be determined in about 1½ hours. The L/S ratio should be determined in those patients in whom there is doubt of fetal maturity and where elective termination of...

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Veröffentlicht in:American journal of obstetrics and gynecology 1972-12, Vol.114 (8), p.1078-1082
Hauptverfasser: Gerbie, Melvin V., Gerbie, Albert B., Boehm, John
Format: Artikel
Sprache:eng
Schlagworte:
Amniocentesis
Amniotic Fluid - analysis
Chromatography, Thin Layer
Creatinine - analysis
Embryonic and Fetal Development
Female
Fetal Diseases - diagnosis
Gestational Age
Humans
Lung - embryology
Phosphatidylcholines - analysis
Pregnancy
Pulmonary Surfactants - analysis
Sphingomyelins - analysis
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Zusammenfassung:A lecithin/sphingomyelin (L/S) ratio of >1.75 indicates pulmonary maturity. With the use of thin-layer chromatography, the L/S ratio can be determined in about 1½ hours. The L/S ratio should be determined in those patients in whom there is doubt of fetal maturity and where elective termination of pregnancy is warranted. Creatinine determination is less helpful in our laboratory because of the wide range of values.
ISSN:0002-9378
1097-6868
DOI:10.1016/0002-9378(72)90872-1