Adaptive and Maladaptive Remodeling of Cardiomyocyte Excitation-Contraction Coupling by Angiotensin II
Chronic elevation of plasma angiotensin II (Ang II) is a major determinant in the pathogenesis of cardiac hypertrophy and congestive heart failure. However, the molecular mechanisms by which the direct actions of Ang II on cardiomyocytes contribute to excitation-contraction coupling (ECC) remodeling...
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| Veröffentlicht in: | Trends in cardiovascular medicine 2010-04, Vol.20 (3), p.78-85 |
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| creator | Egger, Marcel Domenighetti, Andrea A |
| description | Chronic elevation of plasma angiotensin II (Ang II) is a major determinant in the pathogenesis of cardiac hypertrophy and congestive heart failure. However, the molecular mechanisms by which the direct actions of Ang II on cardiomyocytes contribute to excitation-contraction coupling (ECC) remodeling are not precisely known. We review this question, as well as acute Ang II–mediated modulation of ECC. In addition, we discuss adaptive/maladaptive modulation of cardiomyocyte ECC under chronic endogenous Ang II overproduction in the heart induced by local overexpression of the of the renin-angiotensin system in the mouse. |
| doi_str_mv | 10.1016/j.tcm.2010.06.001 |
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| ispartof | Trends in cardiovascular medicine, 2010-04, Vol.20 (3), p.78-85 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adaptation, Physiological Angiotensin II - metabolism Animals Blood pressure Cardiomegaly - metabolism Cardiomegaly - physiopathology Cardiomyocytes Cardiovascular Excitation Contraction Coupling Heart Failure - metabolism Heart Failure - physiopathology Homeostasis Humans Mice Mice, Knockout Myocytes, Cardiac - metabolism Proteins Renin-Angiotensin System - genetics Rodents Ventricular Remodeling |
| title | Adaptive and Maladaptive Remodeling of Cardiomyocyte Excitation-Contraction Coupling by Angiotensin II |
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