Adaptive and Maladaptive Remodeling of Cardiomyocyte Excitation-Contraction Coupling by Angiotensin II

Adaptive and Maladaptive Remodeling of Cardiomyocyte Excitation-Contraction Coupling by Angiotensin II

Chronic elevation of plasma angiotensin II (Ang II) is a major determinant in the pathogenesis of cardiac hypertrophy and congestive heart failure. However, the molecular mechanisms by which the direct actions of Ang II on cardiomyocytes contribute to excitation-contraction coupling (ECC) remodeling...

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Veröffentlicht in:Trends in cardiovascular medicine 2010-04, Vol.20 (3), p.78-85
Hauptverfasser: Egger, Marcel, Domenighetti, Andrea A
Format: Artikel
Sprache:eng
Schlagworte:
Adaptation, Physiological
Angiotensin II - metabolism
Animals
Blood pressure
Cardiomegaly - metabolism
Cardiomegaly - physiopathology
Cardiomyocytes
Cardiovascular
Excitation Contraction Coupling
Heart Failure - metabolism
Heart Failure - physiopathology
Homeostasis
Humans
Mice
Mice, Knockout
Myocytes, Cardiac - metabolism
Proteins
Renin-Angiotensin System - genetics
Rodents
Ventricular Remodeling
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Zusammenfassung:Chronic elevation of plasma angiotensin II (Ang II) is a major determinant in the pathogenesis of cardiac hypertrophy and congestive heart failure. However, the molecular mechanisms by which the direct actions of Ang II on cardiomyocytes contribute to excitation-contraction coupling (ECC) remodeling are not precisely known. We review this question, as well as acute Ang II–mediated modulation of ECC. In addition, we discuss adaptive/maladaptive modulation of cardiomyocyte ECC under chronic endogenous Ang II overproduction in the heart induced by local overexpression of the of the renin-angiotensin system in the mouse.
ISSN:1050-1738
1873-2615
DOI:10.1016/j.tcm.2010.06.001