Glycaemic fall after a glucose load. A population-based study

Abstract Background and aims A blood glucose (BG) fall after an oral glucose load has never been described previously at a population level. This study was aimed at looking for a plasma glucose trend after an oral glucose load for possible blood glucose fall if any, and for its impact on coronary mortality at a population level. Methods and results In subjects from an unselected general population, BG and insulin were detected before and 1 and 2 h after a 75-g oral glucose load for insulin sensitivity and β-cell function determination. Blood pressure, blood examinations and left ventricular mass were measured, and mortality was monitored for 18.8 ± 7.7 years. According to discriminant analysis, the population was stratified into cluster 0 (1-h BG < fasting BG; n = 497) and cluster 1 (1-h BG ≥ fasting BG; n = 1733). To avoid any interference of age and sex, statistical analysis was limited to two age–gender-matched cohorts of 490 subjects from each cluster ( n = 940). Subjects in cluster 0 showed significantly higher insulin sensitivity and β-cell function, lower visceral adiposity and lower blood pressure values. Adjusted coronary mortality was 8 times lower in cluster 0 than 1 ( p < 0.001). The relative risk of belonging to cluster 1 was 5.40 (95% CI 2.22–13.1). Conclusion It seems that two clusters exist in the general population with respect to their response to an oral glucose load, independent of age and gender. Subjects who respond with a BG decrease could represent a privileged sub-population, where insulin sensitivity and β-cell function are better, some risk factors are less prevalent, and coronary mortality is lower.