Influence of Spironolactone and Dexamethasone on Phosphoprotein Phosphatase in the Rat Liver, Kidney and Spleen

Phosphoprotein phosphatase activity is markedly increased in the rat liver, barely stimulated in the kidney, but not influenced in the spleen, by spironolactone treatment. Dexamethasone is ineffective in these respects, whereas cycloheximide, dactinomycin and SKF 525‐A significantly interfered with...

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Veröffentlicht in:	European journal of biochemistry 1972-08, Vol.28 (4), p.475-477
Hauptverfasser:	JapundŽIĆ, Ivanka, MimiĆ‐OKA, Jasmina, JapundŽIĆ, Milorad, SzabÓ, Sándor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caseins Cycloheximide - pharmacology Dactinomycin - pharmacology Dexamethasone - pharmacology Enzyme Induction - drug effects Female Kidney - drug effects Kidney - enzymology Liver - drug effects Liver - enzymology Microsomes - enzymology Phosphoproteins Phosphoric Monoester Hydrolases - biosynthesis Phosphoric Monoester Hydrolases - metabolism Proadifen - pharmacology Rats Spironolactone - antagonists & inhibitors Spironolactone - pharmacology Spleen - drug effects Spleen - enzymology
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Zusammenfassung:	Phosphoprotein phosphatase activity is markedly increased in the rat liver, barely stimulated in the kidney, but not influenced in the spleen, by spironolactone treatment. Dexamethasone is ineffective in these respects, whereas cycloheximide, dactinomycin and SKF 525‐A significantly interfered with the action of spironolactone. Our findings demonstrate that spironolactone can induce both microsomal and extramicrosomal enzymes.
ISSN:	0014-2956 1432-1033
DOI:	10.1111/j.1432-1033.1972.tb01934.x