Studies of the effect of unsaturated fat feeding on cholesterol in the rat

The effects of saturated fat feeding as contrasted with unsaturated fats were studied in rats. The rats on unsaturated fat had lower serum cholesterol and less cholesterol deposition in the aorta, kidney, and liver than those on saturated fats. The animals on unsaturated fat had less deposition of orally fed 14C-cholesterol and iv Na-Ac in these organs than those on saturated fat. Evidence was adduced that the kidney is more efficient than the aorta in removing cholesterol on saturated fat diets.