Human-Mouse Cell Hybrids: A Suggestion of Structural Mutation for Dipeptidase-2 Deficiency in Mouse Cells

Human-Mouse Cell Hybrids: A Suggestion of Structural Mutation for Dipeptidase-2 Deficiency in Mouse Cells

The dipeptidase-2 enzyme is inactive in certain cultured cell lines from the mouse. In somatic cell hybrids between such deficient cells and diploid human fibroblasts, the mouse deficiency was complemented when the homologous human peptidase-A was retained. The results suggested that the murine pept...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1972-10, Vol.178 (4056), p.58-60
Hauptverfasser: Shows, Thomas B., May, Joan, Haley, Linda
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antiserum
Cell Line
Cell lines
Connective Tissue
Dipeptidases - analysis
Dipeptidases - biosynthesis
Electrophoresis, Starch Gel
Enzymes
Fibroblasts
Genes
Genes, Regulator
Genetic mutation
Humans
Hybrid cells
Hybrid Cells - enzymology
Hybridity
Lung
Mice
Mutation
Phenotype
Phenotypes
Somatic cells
Virions
Viruses
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Zusammenfassung:The dipeptidase-2 enzyme is inactive in certain cultured cell lines from the mouse. In somatic cell hybrids between such deficient cells and diploid human fibroblasts, the mouse deficiency was complemented when the homologous human peptidase-A was retained. The results suggested that the murine peptidase deficiency was the result of a structural mutation, rather than a regulatory one.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.178.4056.58