Durable Radioprotection by Oral Administration of 2-Aminoethanethiosulfuric Acid in Mice

Durable Radioprotection by Oral Administration of 2-Aminoethanethiosulfuric Acid in Mice

Oral administration of 2-aminoethianethiosulfuric acid offered a powerful protective action in mice against X-radiation of 600-800R. The effectiveness continued for more than 6hr after ingestion of the compound. The radiation protective. effect of the compound was not observed, however, in the anima...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1972/06/25, Vol.20(6), pp.1102-1104
Hauptverfasser: TAKAGI, YOSHINARI, SHIKITA, MIKIO, AKABOSHI, SANYA
Format: Artikel
Sprache:eng
Schlagworte:
Administration, Oral
Animals
Cysteamine - pharmacology
Cysteine - pharmacology
Ethylamines - administration & dosage
Ethylamines - pharmacology
Injections, Intraperitoneal
Male
Mice
Radiation-Protective Agents
Thiosulfates - administration & dosage
Thiosulfates - pharmacology
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Zusammenfassung:Oral administration of 2-aminoethianethiosulfuric acid offered a powerful protective action in mice against X-radiation of 600-800R. The effectiveness continued for more than 6hr after ingestion of the compound. The radiation protective. effect of the compound was not observed, however, in the animals which received 900RR radiation. S-Sulfocysteine was also radioprotective orally, but the effectiveness faded away in one hr.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.20.1102