GLC Analysis of Menadione Bisulfite Addition Compounds by On-Column Pyrolysis to Menadione

The GC determination of the on-column pyrolysis product of menadione bisulfite addition compounds as menadione is described. Differential thermal analysis, mass spectroscopy, and GC retention times conclusively prove the feasibility of on-column pyrolysis of menadione bisulfite addition compounds to...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1972-09, Vol.61 (9), p.1462-1465
Hauptverfasser:	Winkler, Victor W., Regnier, F.E., Yoder, John M., Macy, Lowell R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, Gas Differential thermal analysis-determination Differential thermal analysis—determination, menadione bisulfite pyrolysis to menadione Drug Stability GC-mass spectroscopy-determination GC-mass spectroscopy—determination, menadione bisulfite pyrolysis to menadione GLC-analysis GLC—analysis, menadione bisulfite via pyrolysis to menadione Mass Spectrometry Menadione bisulfite addition products-GLC analysis Menadione bisulfite addition products—GLC analysis, on-column pyrolysis to menadione, thermal decomposition confirmed by differential thermal analysis and GC-mass spectroscopy menadione bisulfite pyrolysis to menadione menadione bisulfite to menadione-GLC analysis of menadione bisulfite addition products menadione bisulfite via pyrolysis to menadione on-column pyrolysis to menadione Pyrolysis Pyrolysis, menadione bisulfite to menadione—GLC analysis of menadione bisulfite addition products, thermal decomposition confirmed by differential thermal analysis and GC-mass spectroscopy Sulfites Temperature thermal decomposition confirmed by differential thermal analysis and GC-mass spectroscopy Vitamin K
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Zusammenfassung:	The GC determination of the on-column pyrolysis product of menadione bisulfite addition compounds as menadione is described. Differential thermal analysis, mass spectroscopy, and GC retention times conclusively prove the feasibility of on-column pyrolysis of menadione bisulfite addition compounds to menadione. Recovery values of menadione content of powdered and liquid injectable menadione bisufite compounds were the following: menadione sodium bisulfite (trihydrate) powder, 98.59 ± 3.4%, 5 mg./ml. liquid injectable, 97.04 ± 1.46%, and 10 mg./ml. liquid injectable, 100.40 ± 0.50%.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600610925