Effect of Escherichia coli Endotoxin on Temperature and Sleep Cycles of Rats

The lipopolysaccharide from Escherichia coli injected intravenously into rats induces dose-dependent changes of temperature and marked disturbances of sleep cycles. The changes in sleep cycles are characterized mainly by a depression of the total time of paradoxical sleep and seem to be related to t...

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Veröffentlicht in:	The Journal of infectious diseases 1972-08, Vol.126 (2), p.179-181
Hauptverfasser:	Kadlecová, O., Anochina, I. P., Bauer, V., Mašek, K., Rašková, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Temperature - drug effects Dosage Electroencephalography Electromyography Endotoxins Endotoxins - pharmacology Escherichia coli Fever Fever - chemically induced Injections, Intravenous Lipopolysaccharides Lipopolysaccharides - pharmacology Male Pharmacology Polysaccharides, Bacterial - pharmacology Rats Rats, Inbred Strains Sleep Sleep Stages - drug effects Toxins Wakefulness
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Beschreibung
Zusammenfassung:	The lipopolysaccharide from Escherichia coli injected intravenously into rats induces dose-dependent changes of temperature and marked disturbances of sleep cycles. The changes in sleep cycles are characterized mainly by a depression of the total time of paradoxical sleep and seem to be related to the degree of endo-toxin-induced fever.
ISSN:	0022-1899 0537-6613 1537-6613
DOI:	10.1093/infdis/126.2.179