Analysis of the dispersity in carbohydrate loading of synthetic glycoproteins using MALDI-TOF mass spectrometry

Statistical correlation of mass spectrum peak broadening with product dispersity in protein conjugation reactions allows more detailed characterization of putative therapeutic conjugates.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2010-12, Vol.46 (48), p.9119-9121
Hauptverfasser:	Patel, Mitul K, Vijayakrishnan, Balakumar, Koeppe, Julia R, Chalker, Justin M, Doores, Katie J, Davis, Benjamin G
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbohydrates - analysis Data Interpretation, Statistical Glycoproteins - chemistry Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Statistical correlation of mass spectrum peak broadening with product dispersity in protein conjugation reactions allows more detailed characterization of putative therapeutic conjugates.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c0cc03420g