A Selective and Convenient Method for the Synthesis of 2-Phenylaminothiazolines

A Selective and Convenient Method for the Synthesis of 2-Phenylaminothiazolines

A series of 2-phenylaminothiazolines have been prepared from the corresponding N-(2-hydroxyethyl)-N′-phenylthioureas under mild reaction conditions using either thio-CDI (1,1′-thiocarbonyldiimidazole) or CDI (1,1′-carbonyldiimidazole) to promote the cyclization. This protocol provides the desired cy...

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Veröffentlicht in:Organic letters 2010-12, Vol.12 (23), p.5526-5529
Hauptverfasser: Bernacki, April L, Zhu, Lingyang, Hennings, D. David
Format: Artikel
Sprache:eng
Schlagworte:
Cyclization
Molecular Structure
Thiazoles - chemical synthesis
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Zusammenfassung:A series of 2-phenylaminothiazolines have been prepared from the corresponding N-(2-hydroxyethyl)-N′-phenylthioureas under mild reaction conditions using either thio-CDI (1,1′-thiocarbonyldiimidazole) or CDI (1,1′-carbonyldiimidazole) to promote the cyclization. This protocol provides the desired cyclization products in good yield with excellent selectivity. The scope and selectivity of this methodology are also described.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol102428m