Daphnane- and Tigliane-Type Diterpenoid Esters and Orthoesters from Pimelea elongata

Investigation of Pimelea elongata (“Lakebed Pimelea”) afforded 18 tigliane- and daphnane-type diterpenes (1−18). Eight of these were new compounds: four (1−3, 5) tigliane esters and four (7, 8, 10, 11) daphnane orthoesters. The 10 known compounds were 12-O-decanoylphorbol-13-acetate (4), P. simplex...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2010-11, Vol.73 (11), p.1907-1913
Hauptverfasser:	Hayes, Patricia Y, Chow, Sharon, Somerville, Michael J, Fletcher, Mary T, De Voss, James J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Diterpenes - chemistry Diterpenes - isolation & purification Esters Fundamental and applied biological sciences. Psychology Molecular Structure Nuclear Magnetic Resonance, Biomolecular Other biological molecules Stereoisomerism Terpenes, steroids. Hormones Thymelaeaceae - chemistry
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Zusammenfassung:	Investigation of Pimelea elongata (“Lakebed Pimelea”) afforded 18 tigliane- and daphnane-type diterpenes (1−18). Eight of these were new compounds: four (1−3, 5) tigliane esters and four (7, 8, 10, 11) daphnane orthoesters. The 10 known compounds were 12-O-decanoylphorbol-13-acetate (4), P. simplex subtoxin B (6), wikstroelide E (9), pimelotides A and B (12, 13), gnidiglaucin (14), simplexin (15), huratoxin (16), kirkinine D (17), and 12-β-acetoxyhuratoxin (18). The structures and relative configurations of the new compounds were determined by 1D and 2D NMR spectroscopic studies in combination with MS analyses.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np1005746