A Mild Negishi Cross-Coupling of 2-Heterocyclic Organozinc Reagents and Aryl Chlorides

A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides is described. The use of Pd2(dba)3 and X-Phos as a ligand provides high yields for many examples. An efficient method to generate the organozinc reagents at room temperature is also demonstrated.

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Veröffentlicht in:	Journal of organic chemistry 2010-12, Vol.75 (23), p.8330-8332
Hauptverfasser:	Luzung, Michael R, Patel, Jigar S, Yin, Jingjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Cross-Linking Reagents Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Heterocyclic compounds with only one n hetero atom and condensed derivatives Hydrocarbons, Chlorinated - chemistry Indicators and Reagents Magnetic Resonance Spectroscopy Molecular Structure Organic chemistry Organometallic Compounds - chemical synthesis Organometallic Compounds - chemistry Preparations and properties
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Beschreibung
Zusammenfassung:	A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides is described. The use of Pd2(dba)3 and X-Phos as a ligand provides high yields for many examples. An efficient method to generate the organozinc reagents at room temperature is also demonstrated.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo1018798