Expression of Early Immune Response Genes during Physical Exercise

Study by means of expression profiling with Human GeneChip ST1.0 microchips (Affymetrix) revealed 10 early immune response genes, whose expression was modified after short-term intense physical exercise. They include genes for immunoglobulin-like receptors of natural killer cell, genes for IL-2Rβ an...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2010-07, Vol.149 (1), p.89-92
Hauptverfasser:	Shleptsova, V. A, Trushkin, E. V, Bystryh, O. A, Davydov, J. I, Obrazcova, N. P, Grebenuk, E. S, Tonevitsky, A. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cell Biology Exercise Exercise - physiology Gene expression Gene Expression Regulation - immunology Gene Expression Regulation - physiology Genes Granzymes - metabolism Humans Immune response immune system Immunoglobulins Interleukin-2 Receptor beta Subunit - metabolism Internal Medicine Laboratory Medicine Male natural killer cells Oligonucleotide Array Sequence Analysis Pathology Perforin Pore Forming Cytotoxic Proteins - metabolism Receptors, Interleukin-18 - metabolism Receptors, Natural Killer Cell - genetics Receptors, Natural Killer Cell - metabolism Sports Medicine Young Adult
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Zusammenfassung:	Study by means of expression profiling with Human GeneChip ST1.0 microchips (Affymetrix) revealed 10 early immune response genes, whose expression was modified after short-term intense physical exercise. They include genes for immunoglobulin-like receptors of natural killer cell, genes for IL-2Rβ and IL-18RAP receptors, and two genes for functional proteins (perforin 1 and granzyme B) that provide the cytotoxic potential of killer cells. Possible mechanisms of stimulation, activation of the receptor apparatus, and cytotoxic effect on natural killer cells are evaluated under conditions of physical exercise.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-010-0883-6