Coordination to gallium(III) strongly enhances the potency of 2-pyridineformamide thiosemicarbazones against Cryptococcus opportunistic fungi

Coordination to gallium(III) strongly enhances the potency of 2-pyridineformamide thiosemicarbazones against Cryptococcus opportunistic fungi

A family of 2-pyridineformamide-derived thiosemicarbazones and their gallium(III) complexes were tested against several isolates of pathogenic Cryptococcus strains. On complexation the antifungal activity significantly increases, suggesting coordination to gallium(III) to be an interesting strategy...

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Veröffentlicht in:Microbiological research 2010-09, Vol.165 (7), p.573-577
Hauptverfasser: Bastos, Thaíssa de Oliveira, Maria Soares, Betânia, Silva Cisalpino, Patrícia, Castro Mendes, Isolda, dos Santos, Raquel Gouvea, Beraldo, Heloisa
Format: Artikel
Sprache:eng
Schlagworte:
Antifungal activity
Antifungal Agents - pharmacology
Cryptococcosis - microbiology
Cryptococcus
Cryptococcus - drug effects
Drug Synergism
Formamides - pharmacology
Gallium - pharmacology
Gallium complexes
Humans
Microbial Sensitivity Tests
Pyridines - pharmacology
Thiosemicarbazones
Thiosemicarbazones - pharmacology
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Zusammenfassung:A family of 2-pyridineformamide-derived thiosemicarbazones and their gallium(III) complexes were tested against several isolates of pathogenic Cryptococcus strains. On complexation the antifungal activity significantly increases, suggesting coordination to gallium(III) to be an interesting strategy of antifungal dose reduction.
ISSN:0944-5013
1618-0623
DOI:10.1016/j.micres.2009.10.005