Inhibition of Sodium- and Potassium-Dependent Adenosine Triphosphatase by Digoxin Covalently Bound to Sepharose

A procedure for the synthesis of a series of digoxin-derivatized Sepharose compounds is described. These compounds inhibit a soluble (Na+ + K+)-ATPase from rat brain to a degree paralleling the length of the hydrocarbon bridge.

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Bibliographische Detailangaben
Veröffentlicht in:	Molecular pharmacology 1972-07, Vol.8 (4), p.476-480
Hauptverfasser:	OKARMA, T.B., TRAMELL, P., KALMAN, S.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - antagonists & inhibitors Alkylation Amines Animals Brain - enzymology Chemical Phenomena Chemistry Digoxin Polysaccharides Potassium Protein Binding Rats Sodium Structure-Activity Relationship
Online-Zugang:	Volltext
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