Inhibition of Sodium- and Potassium-Dependent Adenosine Triphosphatase by Digoxin Covalently Bound to Sepharose

Inhibition of Sodium- and Potassium-Dependent Adenosine Triphosphatase by Digoxin Covalently Bound to Sepharose

A procedure for the synthesis of a series of digoxin-derivatized Sepharose compounds is described. These compounds inhibit a soluble (Na+ + K+)-ATPase from rat brain to a degree paralleling the length of the hydrocarbon bridge.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecular pharmacology 1972-07, Vol.8 (4), p.476-480
Hauptverfasser: OKARMA, T.B., TRAMELL, P., KALMAN, S.M.
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine Triphosphatases - antagonists & inhibitors
Alkylation
Amines
Animals
Brain - enzymology
Chemical Phenomena
Chemistry
Digoxin
Polysaccharides
Potassium
Protein Binding
Rats
Sodium
Structure-Activity Relationship
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A procedure for the synthesis of a series of digoxin-derivatized Sepharose compounds is described. These compounds inhibit a soluble (Na+ + K+)-ATPase from rat brain to a degree paralleling the length of the hydrocarbon bridge.
ISSN:0026-895X
1521-0111
DOI:10.1016/S0026-895X(25)12782-X