Structure and Activity of Thiazole-Type Schistosomicidal Agents

The schistosomicidal agent 1-(5′-nitro-2′-thiazolyl)-2-imidazolidinone caused a rise in the α-keto acid level when given orally to rats. This effect could be diminished upon parallel administration of high doses of the vitamin thiamine. The biological effect of the drug could also be canceled throug...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1972-08, Vol.61 (8), p.1327-1328
Hauptverfasser:	Nabih, I., El-Hawary, F., Zoorob, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5′-Nitro-2′-thiazolyl)-2-imidazolidinone-structure-schistosomicidal activity 1-(5′-Nitro-2′-thiazolyl)-2-imidazolidinone—structure-schistosomicidal activity, biological studies, compared to thiamine Animals Anthelmintics - pharmacology Anthelmintics - therapeutic use biological studies Biotin - pharmacology compared to thiamine Imidazoles - pharmacology Imidazoles - therapeutic use Mice Niridazole - pharmacology Niridazole - therapeutic use Niridazole-structure-schistosomicidal activity Niridazole—structure-schistosomicidal activity, biological studies, compared to thiamine Pyruvates - blood Rats Rats, Inbred Strains Schistosoma mansoni - drug effects Schistosomiasis - drug therapy Schistosomicidal agents Schistosomicidal agents, thiazole type—1-(5′-nitro-2′-thiazolyl)2-imidazolidinone, structure-activity, compared to thiamine, biological studies structure relationships structure-activity Structure-Activity Relationship Thiamine - antagonists & inhibitors Thiamine-effect on oral administration of 1-(5′-nitro-2′-thiazolyl)-2-imidazolidinone Thiamine—effect on oral administration of 1-(5′-nitro-2′-thiazolyl)-2-imidazolidinone, structure relationships thiazole type-1-(5′-nitro-2′-thiazolyl)2-imidazolidinone Thiazole-type schistosomicidal agents-1-(5′-nitro-2′-thiazolyl)-2-imidazolidinone Thiazole-type schistosomicidal agents—1-(5′-nitro-2′-thiazolyl)-2-imidazolidinone, structure-activity, compared to thiamine, biological studies Thiazoles - pharmacology Thiazoles - therapeutic use
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Beschreibung
Zusammenfassung:	The schistosomicidal agent 1-(5′-nitro-2′-thiazolyl)-2-imidazolidinone caused a rise in the α-keto acid level when given orally to rats. This effect could be diminished upon parallel administration of high doses of the vitamin thiamine. The biological effect of the drug could also be canceled through similar administration of the vitamin.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600610838