Glucocorticoids and Gastric Secretion: The Role of Cyclic Adenosine-3′, 5′-Monophosphate

The role of adenosine-3′,5′-monophosphate (cyclic AMP) in glucocorticoid action on gastric acid secretion was studied in rats. In adrenalectomized animals, the gastric acid output, as well as the cyclic AMP content of gastric mucosa, were reduced about 60% as compared with control animals. Both the...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1972-08, Vol.63 (2), p.252-256
Hauptverfasser:	Domschke, Wolfram, Domschke, Sigurd, Classen, Meinhard, Demling, Ludwig
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - physiology Adrenalectomy Animals Cyclic AMP - metabolism Cyclic AMP - physiology Dexamethasone - pharmacology Gastric Juice - secretion Gastric Mucosa - drug effects Gastric Mucosa - metabolism Male Pentagastrin - pharmacology Rats Tritium
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Zusammenfassung:	The role of adenosine-3′,5′-monophosphate (cyclic AMP) in glucocorticoid action on gastric acid secretion was studied in rats. In adrenalectomized animals, the gastric acid output, as well as the cyclic AMP content of gastric mucosa, were reduced about 60% as compared with control animals. Both the parameters were restored almost to normal by replacement therapy with dexamethasone. In intact animals, however, this glucocorticoid did not exert any statistically verifiable effect on gastric acid secretion or on cyclic AMP content of gastric mucosa either. From these results, glucocorticoids may play their permissive role in gastric acid secretion via a permissive action on net cyclic AMP production.
ISSN:	0016-5085 1528-0012
DOI:	10.1016/S0016-5085(19)33311-6