A STUDY OF THE STRUCTURE OF BLUENSOMYCIN WITH THE TETRAMMINECOPPER REAGENT

A STUDY OF THE STRUCTURE OF BLUENSOMYCIN WITH THE TETRAMMINECOPPER REAGENT

A polarimetric study was made of the interaction of the tetramminecopper (TACu) reagent and the Cupra B reagent with bluensomycin, desamidinodecarbamoyl (DADC) bluensomycin, and several reference compounds of the streptomycin series. The results obtained with TACu support the choice of 5b as the cor...

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Veröffentlicht in:Journal of antibiotics 1972/05/25, Vol.25(5), pp.281-286
Hauptverfasser: BARLOW, G. B., ANDERSON, LAURENS
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents
Chemical Phenomena
Chemistry
Copper
Dihydrostreptomycin Sulfate
Glucosamine
Glucosephosphates
Indicators and Reagents
Models, Chemical
Optical Rotation
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Zusammenfassung:A polarimetric study was made of the interaction of the tetramminecopper (TACu) reagent and the Cupra B reagent with bluensomycin, desamidinodecarbamoyl (DADC) bluensomycin, and several reference compounds of the streptomycin series. The results obtained with TACu support the choice of 5b as the correct formula for DADC-bluensomycin. It follows that bluensomycin is 9, and bluensidine is 1D-1-O-carbamoyl-3-deoxy-3-guanidino-scyllo-inositol (2). A phosphorylated aminosugar, D-glucosamine 1-phosphate, gives a normal Δ[M] value with TACu.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.25.281