Chromosomal Aberrations Induced by N-Methyl-N'-Nitro-N-Nitrosoguanidine in Mammalian Cells

Populations of a heteroploid Chinese hamster cell line were exposed to single and multiple doses of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and examined for chromosomal aberrations. Cells exposed to 0.5 µg per ml MNNG did not differ significantly from those exposed to 1.0 µg per ml MNNG in...

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Veröffentlicht in:	In vitro 1972-05, Vol.7 (6), p.359-365
Hauptverfasser:	Patricia N. Howard, Bloom, Arthur D., Krooth, Robert S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell culture techniques Cell cycle Cell Line Cell lines Chinese hamsters Chromatids - drug effects Chromosome aberrations Chromosome Aberrations - drug effects Chromosomes Colchicine Cricetinae Cultured cells Diploidy DNA Guanidines - pharmacology Karyotyping Lung Lungs Methods Nitroso Compounds - pharmacology Nitrosoguanidines - pharmacology Trypsin
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