Calcium efflux and respiratory inhibition in brain mitochondria: Effects of chlorpromazine metabolites

7-Hydroxychlorpromazine was found to be similar to chlorpromazine in its ability to inhibit brain mitochondrial calcium accumulation and respiration. 7,8-Dihydroxychlorpromazine, however, was found to produce a marked efflux of calcium accumulated by these mitochondrial preparations in the presence...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical and biophysical research communications 1972-07, Vol.48 (1), p.212-218
Hauptverfasser:	Tjioe, Sarah A., Manian, Albert A., O'Neill, John J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Animals Biological Transport - drug effects Brain - cytology Brain - drug effects Brain - metabolism Calcium - metabolism Calcium Isotopes Chlorpromazine - pharmacology Kinetics Mitochondria - drug effects Mitochondria - metabolism Oxygen Consumption - drug effects Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!