Calcium efflux and respiratory inhibition in brain mitochondria: Effects of chlorpromazine metabolites

7-Hydroxychlorpromazine was found to be similar to chlorpromazine in its ability to inhibit brain mitochondrial calcium accumulation and respiration. 7,8-Dihydroxychlorpromazine, however, was found to produce a marked efflux of calcium accumulated by these mitochondrial preparations in the presence...

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Veröffentlicht in:Biochemical and biophysical research communications 1972-07, Vol.48 (1), p.212-218
Hauptverfasser: Tjioe, Sarah A., Manian, Albert A., O'Neill, John J.
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Sprache:eng
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Zusammenfassung:7-Hydroxychlorpromazine was found to be similar to chlorpromazine in its ability to inhibit brain mitochondrial calcium accumulation and respiration. 7,8-Dihydroxychlorpromazine, however, was found to produce a marked efflux of calcium accumulated by these mitochondrial preparations in the presence of ATP. In addition, this metabolite or one of its orthoquinone forms was observed to gradually inhibit state 4 respiration and prevent the stimulation of oxygen uptake normally observed upon the addition of phosphate and phosphate acceptor. The possible importance of sulfhydryl groups in these inhibitory actions is discussed.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(72)90365-8