Calcium efflux and respiratory inhibition in brain mitochondria: Effects of chlorpromazine metabolites
7-Hydroxychlorpromazine was found to be similar to chlorpromazine in its ability to inhibit brain mitochondrial calcium accumulation and respiration. 7,8-Dihydroxychlorpromazine, however, was found to produce a marked efflux of calcium accumulated by these mitochondrial preparations in the presence...
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Veröffentlicht in: | Biochemical and biophysical research communications 1972-07, Vol.48 (1), p.212-218 |
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Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | 7-Hydroxychlorpromazine was found to be similar to chlorpromazine in its ability to inhibit brain mitochondrial calcium accumulation and respiration. 7,8-Dihydroxychlorpromazine, however, was found to produce a marked efflux of calcium accumulated by these mitochondrial preparations in the presence of ATP. In addition, this metabolite or one of its orthoquinone forms was observed to gradually inhibit state 4 respiration and prevent the stimulation of oxygen uptake normally observed upon the addition of phosphate and phosphate acceptor. The possible importance of sulfhydryl groups in these inhibitory actions is discussed. |
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ISSN: | 0006-291X 1090-2104 |
DOI: | 10.1016/0006-291X(72)90365-8 |