Pitting Function of the Spleen in Malaria: Ultrastructural Observations
Ultrastructural studies of spleens from monkeys infected with Plasmodium knowlesi suggest that the spleen removes or "pits" malaria parasites from red cells. This function may explain the presence of nonparasitized spherocytic erythrocytes in the peripheral blood and may in part account fo...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1972-07, Vol.177 (4044), p.175-177 |
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| container_end_page | 177 |
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| container_issue | 4044 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Schnitzer, Bertram Sodeman, Thomas Mead, Michael L. Contacos, Peter G. |
| description | Ultrastructural studies of spleens from monkeys infected with Plasmodium knowlesi suggest that the spleen removes or "pits" malaria parasites from red cells. This function may explain the presence of nonparasitized spherocytic erythrocytes in the peripheral blood and may in part account for the discrepancy between the excessive hemolysis and the number of parasitized erythrocytes in animals with experimentally induced malaria. |
| doi_str_mv | 10.1126/science.177.4044.175 |
| format | Article |
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This function may explain the presence of nonparasitized spherocytic erythrocytes in the peripheral blood and may in part account for the discrepancy between the excessive hemolysis and the number of parasitized erythrocytes in animals with experimentally induced malaria.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.177.4044.175</identifier><identifier>PMID: 4339353</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animals ; Erythrocytes ; Erythrocytes - analysis ; Erythrocytes - microbiology ; Haplorhini ; Hemolysis ; Hormones ; Inclusion Bodies - analysis ; Macaca ; Macrophages - analysis ; Malaria ; Malaria - physiopathology ; Parasites ; Parasitism ; Pitting ; Protons ; Sinuses ; Spleen ; Spleen - microbiology ; Spleen - pathology ; Spleen - physiopathology ; Splenectomy</subject><ispartof>Science (American Association for the Advancement of Science), 1972-07, Vol.177 (4044), p.175-177</ispartof><rights>Copyright 1971 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-423f625be00ab3253b9158944ce43d8dd806dde46268e0618147f1536d532f3c3</citedby><cites>FETCH-LOGICAL-c399t-423f625be00ab3253b9158944ce43d8dd806dde46268e0618147f1536d532f3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1734837$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1734837$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2870,2871,27903,27904,57996,58229</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4339353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schnitzer, Bertram</creatorcontrib><creatorcontrib>Sodeman, Thomas</creatorcontrib><creatorcontrib>Mead, Michael L.</creatorcontrib><creatorcontrib>Contacos, Peter G.</creatorcontrib><title>Pitting Function of the Spleen in Malaria: Ultrastructural Observations</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Ultrastructural studies of spleens from monkeys infected with Plasmodium knowlesi suggest that the spleen removes or "pits" malaria parasites from red cells. This function may explain the presence of nonparasitized spherocytic erythrocytes in the peripheral blood and may in part account for the discrepancy between the excessive hemolysis and the number of parasitized erythrocytes in animals with experimentally induced malaria.</description><subject>Animals</subject><subject>Erythrocytes</subject><subject>Erythrocytes - analysis</subject><subject>Erythrocytes - microbiology</subject><subject>Haplorhini</subject><subject>Hemolysis</subject><subject>Hormones</subject><subject>Inclusion Bodies - analysis</subject><subject>Macaca</subject><subject>Macrophages - analysis</subject><subject>Malaria</subject><subject>Malaria - physiopathology</subject><subject>Parasites</subject><subject>Parasitism</subject><subject>Pitting</subject><subject>Protons</subject><subject>Sinuses</subject><subject>Spleen</subject><subject>Spleen - microbiology</subject><subject>Spleen - pathology</subject><subject>Spleen - physiopathology</subject><subject>Splenectomy</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LwzAcxoMoc06_wYSevHUm-Sdp4k3ETWEyQXcOaZpqRtfOJBX89nZs6Ol54Hk5_BCaEjwjhIrbaL1rrZuRopgxzNhg-AkaE6x4riiGUzTGGEQuccHP0UWMG4yHTMEIjRiAAg5jtHj1Kfn2I5v3rU2-a7OuztKny952jXNt5tvsxTQmeHOXrZsUTEyht6kPpslWZXTh2-xX8RKd1aaJ7uqoE7SeP74_POXL1eL54X6ZW1Aq5YxCLSgvHcamBMqhVIRLxZh1DCpZVRKLqnJMUCEdFkQSVtSEg6g40BosTNDN4XcXuq_exaS3PlrXNKZ1XR-1JBxzTNVQZIeiDV2MwdV6F_zWhB9NsN7z00d-euCn9_wGw4fZ9fG_L7eu-hsdgQ359JBvYurC_2cBTEIBv5fddkQ</recordid><startdate>19720714</startdate><enddate>19720714</enddate><creator>Schnitzer, Bertram</creator><creator>Sodeman, Thomas</creator><creator>Mead, Michael L.</creator><creator>Contacos, Peter G.</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19720714</creationdate><title>Pitting Function of the Spleen in Malaria: Ultrastructural Observations</title><author>Schnitzer, Bertram ; Sodeman, Thomas ; Mead, Michael L. ; Contacos, Peter G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-423f625be00ab3253b9158944ce43d8dd806dde46268e0618147f1536d532f3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Animals</topic><topic>Erythrocytes</topic><topic>Erythrocytes - analysis</topic><topic>Erythrocytes - microbiology</topic><topic>Haplorhini</topic><topic>Hemolysis</topic><topic>Hormones</topic><topic>Inclusion Bodies - analysis</topic><topic>Macaca</topic><topic>Macrophages - analysis</topic><topic>Malaria</topic><topic>Malaria - physiopathology</topic><topic>Parasites</topic><topic>Parasitism</topic><topic>Pitting</topic><topic>Protons</topic><topic>Sinuses</topic><topic>Spleen</topic><topic>Spleen - microbiology</topic><topic>Spleen - pathology</topic><topic>Spleen - physiopathology</topic><topic>Splenectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schnitzer, Bertram</creatorcontrib><creatorcontrib>Sodeman, Thomas</creatorcontrib><creatorcontrib>Mead, Michael L.</creatorcontrib><creatorcontrib>Contacos, Peter G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schnitzer, Bertram</au><au>Sodeman, Thomas</au><au>Mead, Michael L.</au><au>Contacos, Peter G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pitting Function of the Spleen in Malaria: Ultrastructural Observations</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1972-07-14</date><risdate>1972</risdate><volume>177</volume><issue>4044</issue><spage>175</spage><epage>177</epage><pages>175-177</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Ultrastructural studies of spleens from monkeys infected with Plasmodium knowlesi suggest that the spleen removes or "pits" malaria parasites from red cells. This function may explain the presence of nonparasitized spherocytic erythrocytes in the peripheral blood and may in part account for the discrepancy between the excessive hemolysis and the number of parasitized erythrocytes in animals with experimentally induced malaria.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>4339353</pmid><doi>10.1126/science.177.4044.175</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1972-07, Vol.177 (4044), p.175-177 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Animals Erythrocytes Erythrocytes - analysis Erythrocytes - microbiology Haplorhini Hemolysis Hormones Inclusion Bodies - analysis Macaca Macrophages - analysis Malaria Malaria - physiopathology Parasites Parasitism Pitting Protons Sinuses Spleen Spleen - microbiology Spleen - pathology Spleen - physiopathology Splenectomy |
| title | Pitting Function of the Spleen in Malaria: Ultrastructural Observations |
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