Pitting Function of the Spleen in Malaria: Ultrastructural Observations

Ultrastructural studies of spleens from monkeys infected with Plasmodium knowlesi suggest that the spleen removes or "pits" malaria parasites from red cells. This function may explain the presence of nonparasitized spherocytic erythrocytes in the peripheral blood and may in part account fo...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1972-07, Vol.177 (4044), p.175-177
Hauptverfasser:	Schnitzer, Bertram, Sodeman, Thomas, Mead, Michael L., Contacos, Peter G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Erythrocytes Erythrocytes - analysis Erythrocytes - microbiology Haplorhini Hemolysis Hormones Inclusion Bodies - analysis Macaca Macrophages - analysis Malaria Malaria - physiopathology Parasites Parasitism Pitting Protons Sinuses Spleen Spleen - microbiology Spleen - pathology Spleen - physiopathology Splenectomy
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Beschreibung
Zusammenfassung:	Ultrastructural studies of spleens from monkeys infected with Plasmodium knowlesi suggest that the spleen removes or "pits" malaria parasites from red cells. This function may explain the presence of nonparasitized spherocytic erythrocytes in the peripheral blood and may in part account for the discrepancy between the excessive hemolysis and the number of parasitized erythrocytes in animals with experimentally induced malaria.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.177.4044.175