Composition and State of Protein in Heart Muscle of Normal Dogs and Dogs with Experimental Myocardial Failure

In comparing protein composition of cardiac muscle of normal dogs and dogs with experimental valvular lesions and chronic heart failure, it was found that the concentration of actomyosin was lower in the experimental than in normal dogs. Furthermore, cardiac actomyosin in the experimental animals showed decreased viscosity, decreased viscosity response to ATP, and sedimentation patterns that differed from the normal.