Induction of polynucleotide ligase in human lymphocytes stimulated by phytohemoagglutinin
The treatment of human lymphocytes with phytohemoagglutinin causes the appearance of the activity of polynucleotide ligase, rising at least 50 fold from levels below the background. This increase takes place in the fourth or fifth day after treatment, and is delayed by one day approximately with res...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1972-06, Vol.47 (5), p.1221-1227 |
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| container_issue | 5 |
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| container_title | Biochemical and biophysical research communications |
| container_volume | 47 |
| creator | Pedrini, Antonia M. Nuzzo, Fiorella Ciarrocchi, Giovanni Dalprà, Leda Falaschi, Arturo |
| description | The treatment of human lymphocytes with phytohemoagglutinin causes the appearance of the activity of polynucleotide ligase, rising at least 50 fold from levels below the background. This increase takes place in the fourth or fifth day after treatment, and is delayed by one day approximately with respect to the rise of DNA synthesis rate; the activity of two other enzymes of DNA metabolism, DNA polymerase and a DNase acting on single-stranded DNA, increases in parallel with the DNA synthesis rate. |
| doi_str_mv | 10.1016/0006-291X(72)90965-5 |
| format | Article |
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| ispartof | Biochemical and biophysical research communications, 1972-06, Vol.47 (5), p.1221-1227 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Deoxyribonucleases DNA - biosynthesis DNA Nucleotidyltransferases DNA Repair DNA, Single-Stranded - metabolism Enzyme Induction Humans In Vitro Techniques Lectins - pharmacology Ligases - biosynthesis Lymphocytes - enzymology Lymphocytes - metabolism Male Stimulation, Chemical Thymidine - metabolism Tritium |
| title | Induction of polynucleotide ligase in human lymphocytes stimulated by phytohemoagglutinin |
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