Induction of polynucleotide ligase in human lymphocytes stimulated by phytohemoagglutinin

The treatment of human lymphocytes with phytohemoagglutinin causes the appearance of the activity of polynucleotide ligase, rising at least 50 fold from levels below the background. This increase takes place in the fourth or fifth day after treatment, and is delayed by one day approximately with res...

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Veröffentlicht in:	Biochemical and biophysical research communications 1972-06, Vol.47 (5), p.1221-1227
Hauptverfasser:	Pedrini, Antonia M., Nuzzo, Fiorella, Ciarrocchi, Giovanni, Dalprà, Leda, Falaschi, Arturo
Format:	Artikel
Sprache:	eng
Schlagworte:	Deoxyribonucleases DNA - biosynthesis DNA Nucleotidyltransferases DNA Repair DNA, Single-Stranded - metabolism Enzyme Induction Humans In Vitro Techniques Lectins - pharmacology Ligases - biosynthesis Lymphocytes - enzymology Lymphocytes - metabolism Male Stimulation, Chemical Thymidine - metabolism Tritium
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Zusammenfassung:	The treatment of human lymphocytes with phytohemoagglutinin causes the appearance of the activity of polynucleotide ligase, rising at least 50 fold from levels below the background. This increase takes place in the fourth or fifth day after treatment, and is delayed by one day approximately with respect to the rise of DNA synthesis rate; the activity of two other enzymes of DNA metabolism, DNA polymerase and a DNase acting on single-stranded DNA, increases in parallel with the DNA synthesis rate.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(72)90965-5