Reverse Transcriptase, RNA Tumour Virus Transformation and Derivatives of Rifamycin SV

A direct correlation was observed between inhibition of focus formation and of reverse transcriptase of murine leukaemia-sarcoma virus by rifamycin derivatives. This suggests that reverse transcriptase is necessary for transformation by RNA tumour viruses.

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Veröffentlicht in:	Nature. New biology (London) 1972-04, Vol.236 (67), p.163-166
Hauptverfasser:	TING, ROBERT C, YANG, STRINGNER S, GALLO, ROBERT C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Cell Division - drug effects Cell Transformation, Neoplastic - drug effects Cells, Cultured DNA Nucleotidyltransferases - antagonists & inhibitors Gammaretrovirus - enzymology Gammaretrovirus - growth & development Kidney Life Sciences Moloney murine leukemia virus - enzymology Rats Rauscher Virus - enzymology Reverse Transcriptase Inhibitors Rifampin - pharmacology Vesicular stomatitis Indiana virus - enzymology
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Beschreibung
Zusammenfassung:	A direct correlation was observed between inhibition of focus formation and of reverse transcriptase of murine leukaemia-sarcoma virus by rifamycin derivatives. This suggests that reverse transcriptase is necessary for transformation by RNA tumour viruses.
ISSN:	0090-0028 2058-1092
DOI:	10.1038/newbio236163a0