Hyperprolinemia and Prolinuria in a New Inbred Strain of Mice, PRO/Re

A hyperprolinemia was discovered, in a new inbred strain of mice, which was equivalent to about a sevenfold elevation above the concentration of proline in the blood of either of the original parental lines, or of 12 other inbred strains with diverse genetic constitution. In addition, mice of this P...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1972-05, Vol.176 (4036), p.809-811
Hauptverfasser:	Blake, R. L., Russell, E. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Metabolism, Inborn Errors - blood Amino Acid Metabolism, Inborn Errors - genetics Amino Acid Metabolism, Inborn Errors - urine Amino Acid Metabolism, Inborn Errors - veterinary Amino acids Amino Acids - urine Animals Blood Chromatography, Paper Cytochalasins Electrophoresis Enzymes Female Inbred strains Liver Male Mice Mice, Inbred Strains Neurons Paper chromatography Proline - blood Proline - metabolism Proline - urine Reagents Rodent Diseases - blood Rodent Diseases - genetics Rodent Diseases - urine Urine
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Beschreibung
Zusammenfassung:	A hyperprolinemia was discovered, in a new inbred strain of mice, which was equivalent to about a sevenfold elevation above the concentration of proline in the blood of either of the original parental lines, or of 12 other inbred strains with diverse genetic constitution. In addition, mice of this PRO/Re strain exhibited a marked prolinuria, whereas the other 14 inbred strains had no proline detectable in their urine.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.176.4036.809