Cobalt-catalyzed intramolecular C-N and C-O cross-coupling reactions: synthesis of benzimidazoles and benzoxazoles

Cobalt-catalyzed intramolecular C-N and C-O cross-coupling reactions: synthesis of benzimidazoles and benzoxazoles

Cobalt(ii)-complex catalyzes efficiently the intramolecular C-N and C-O cross-couplings of Z-N'-(2-halophenyl)-N-phenylamidines and N-(2-bromophenyl)benzamides to afford the corresponding substituted benzimidazoles and benzoxazoles in the presence of K(2)CO(3) at moderate temperature. The proto...

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Veröffentlicht in:Organic & biomolecular chemistry 2010-12, Vol.8 (24), p.5692-5699
Hauptverfasser: Saha, Prasenjit, Ali, Md Ashif, Ghosh, Pokhraj, Punniyamurthy, Tharmalingam
Format: Artikel
Sprache:eng
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Zusammenfassung:Cobalt(ii)-complex catalyzes efficiently the intramolecular C-N and C-O cross-couplings of Z-N'-(2-halophenyl)-N-phenylamidines and N-(2-bromophenyl)benzamides to afford the corresponding substituted benzimidazoles and benzoxazoles in the presence of K(2)CO(3) at moderate temperature. The protocol is general, air stable and affords the products selectively in moderate to high yield.
ISSN:1477-0520
1477-0539
DOI:10.1039/c0ob00405g