Amyloidosis with cardiac involvement

Prognosis is poor with a median survival of 4 months in patients presenting with heart failure. 1 The echocardiograph often shows a thickened left ventricle with a granular speckled appearance due to myocardial infiltration. Late gadolinium imaging often shows a characteristic pattern of global sube...

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Veröffentlicht in:	Postgraduate medical journal 2010-12, Vol.86 (1022), p.742-743
Hauptverfasser:	Yong, Adrian Sze Wai, Aziz, Shahid
Format:	Artikel
Sprache:	eng
Schlagworte:	adult cardiology Aged Amyloidosis Amyloidosis - diagnosis Biological and medical sciences cardiac Cardiac arrhythmia Chemotherapy colon Colonic Diseases - diagnosis echo echocardiography Electrocardiography General aspects Heart attacks Heart Diseases - diagnosis Heart failure Humans Immunoglobulins Intensive care Male Medical prognosis Medical sciences Metabolic diseases nephrology Other metabolic disorders pacing & electrophysiology Proteins renal Tomography, X-Ray Computed Ultrasonic imaging Urine
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Beschreibung
Zusammenfassung:	Prognosis is poor with a median survival of 4 months in patients presenting with heart failure. 1 The echocardiograph often shows a thickened left ventricle with a granular speckled appearance due to myocardial infiltration. Late gadolinium imaging often shows a characteristic pattern of global subendocardial enhancement which is thought to reflect increased amyloid deposition in the endocardium. 2 Chemotherapy targeting clonal plasma cells can reduce circulating free light chains and improve survival in patients with systemic AL amyloidosis. 3 Assays measuring serum free light chain levels can be used to monitor treatment.
ISSN:	0032-5473 1469-0756
DOI:	10.1136/pgmj.2010.106831