Aromatase inhibitors in women with clomiphene citrate resistance: a randomized, double-blind, placebo-controlled trial

In 36 women with polycystic ovary syndrome and clomiphene citrate resistance, letrozole, an aromatase inhibitor, statistically significantly increased the ovulation rate by 33.3% in the treatment group, indicating that letrozole can be used as an effective and simple alternate ovulation-inducing age...

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Veröffentlicht in:	Fertility and sterility 2010-12, Vol.94 (7), p.2857-2859
Hauptverfasser:	Kamath, Mohan S., M.S., D.N.B, Aleyamma, T.K., M.D., D.N.B, Chandy, Achamma, D.G.O, George, Korula, M.D., M.R.A.C.O.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aromatase inhibitor Aromatase Inhibitors - pharmacology Aromatase Inhibitors - therapeutic use Biological and medical sciences Clomiphene - pharmacology Clomiphene - therapeutic use clomiphene resistance Double-Blind Method Drug Resistance - drug effects Drug Resistance - physiology Female Fertility Agents, Female - pharmacology Fertility Agents, Female - therapeutic use Gynecology. Andrology. Obstetrics Humans Infant, Newborn Infertility, Female - drug therapy Internal Medicine letrozole Medical sciences Nitriles - pharmacology Nitriles - therapeutic use Obstetrics and Gynecology Ovulation - drug effects Ovulation - physiology Pregnancy Pregnancy Rate Treatment Failure Triazoles - pharmacology Triazoles - therapeutic use Young Adult
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Zusammenfassung:	In 36 women with polycystic ovary syndrome and clomiphene citrate resistance, letrozole, an aromatase inhibitor, statistically significantly increased the ovulation rate by 33.3% in the treatment group, indicating that letrozole can be used as an effective and simple alternate ovulation-inducing agent in these women.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2010.06.008