Elevated antithyroid peroxidase antibodies indicating Hashimoto's thyroiditis are associated with the treatment response in infertile women with polycystic ovary syndrome

In infertile women suffering from polycystic ovary syndrome (PCOS), anti-thyroid peroxidase antibodies values exceeding the upper level of normal were found in significantly more clomiphene citrate resistant patients compared clomiphene citrate responders and metformin responders. Thus, elevated ant...

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Veröffentlicht in:	Fertility and sterility 2010-12, Vol.94 (7), p.2895-2897
Hauptverfasser:	Ott, Johannes, M.D, Aust, Stefanie, M.D, Kurz, Christine, M.D, Nouri, Kazem, M.D, Wirth, Stefan, M.D, Huber, Johannes C., M.D., Ph.D, Mayerhofer, Klaus, M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult antithyroid peroxidase antibodies Autoantibodies - analysis Autoantibodies - blood Autoantigens - immunology Autoimmune thyroiditis Biological and medical sciences Biomarkers, Pharmacological - blood Clomiphene - therapeutic use clomiphene citrate resistance Drug Resistance - immunology Endocrinopathies Female Female genital diseases Fertility Agents, Female - therapeutic use Fertilization in Vitro - methods Gynecology. Andrology. Obstetrics Hashimoto Disease - blood Hashimoto Disease - complications Hashimoto Disease - diagnosis Hashimoto Disease - immunology Hashimoto's thyroiditis Humans Infertility, Female - blood Infertility, Female - complications Infertility, Female - diagnosis Infertility, Female - drug therapy Internal Medicine Iodide Peroxidase - immunology Iron-Binding Proteins - immunology Medical sciences Non tumoral diseases Non tumoral diseases. Target tissue resistance. Benign neoplasms Obstetrics and Gynecology Ovulation Induction - methods polycystic ovary syndrome Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - immunology Pregnancy Prognosis Retrospective Studies Thyroid. Thyroid axis (diseases) Young Adult
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Zusammenfassung:	In infertile women suffering from polycystic ovary syndrome (PCOS), anti-thyroid peroxidase antibodies values exceeding the upper level of normal were found in significantly more clomiphene citrate resistant patients compared clomiphene citrate responders and metformin responders. Thus, elevated antiTPO levels are associated with poor treatment response in infertile women who suffer from PCOS.
ISSN:	0015-0282 1556-5653
DOI:	10.1016/j.fertnstert.2010.05.063