Effect of Adrenaline, Noradrenaline and Isoprenaline on Hepatic Bile Secretion of Anaesthetized Dogs

MANY reports of the influence of adrenaline on bile secretion have been published in recent years. Engstrand 1 reported an initial increase followed by a decrease, but others 2–6 have reported decreased biliary output after administration of adrenaline. Ramprasad and Sirsi 6 also found decreased biliary output when noradrenaline was infused. The effect of isoprenaline (isopropylarterenol), which is thought to be a specific, beta-adrenergic stimulant 7 on bile secretion, does not, however, appear to have been investigated so far. The present work was undertaken to study this aspect.