Glucose-6-phosphate Dehydrogenase in the Developing Human Liver
Summary G-6-PD was studied in human liver at various stages of development. Distinct differences were observed in specific activity, pH optimum, and thermal stability of the fetal enzyme compared to newborn and adult enzyme. In contrast, no differences were observed in Michaelis-Menten constants or...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1972-03, Vol.139 (3), p.778-782 |
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| container_end_page | 782 |
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| container_issue | 3 |
| container_start_page | 778 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 139 |
| creator | Messina, Anita M. Chacko, Claramma M. Nadler, Henry L. |
| description | Summary
G-6-PD was studied in human liver at various stages of development. Distinct differences were observed in specific activity, pH optimum, and thermal stability of the fetal enzyme compared to newborn and adult enzyme. In contrast, no differences were observed in Michaelis-Menten constants or electrophoretic mobility.
These studies were supported by grants from the National Institutes of Health (R.R. 05475-08 and HD 00036) and the National Foundation—March of Dimes (CRS-61). Henry L. Nadler is the Given Research Professor of Pediatrics. |
| doi_str_mv | 10.3181/00379727-139-36236 |
| format | Article |
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G-6-PD was studied in human liver at various stages of development. Distinct differences were observed in specific activity, pH optimum, and thermal stability of the fetal enzyme compared to newborn and adult enzyme. In contrast, no differences were observed in Michaelis-Menten constants or electrophoretic mobility.
These studies were supported by grants from the National Institutes of Health (R.R. 05475-08 and HD 00036) and the National Foundation—March of Dimes (CRS-61). Henry L. Nadler is the Given Research Professor of Pediatrics.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-139-36236</identifier><identifier>PMID: 5023765</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Drug Stability ; Electrophoresis ; Female ; Fetus ; Glucosephosphate Dehydrogenase - metabolism ; Hot Temperature ; Humans ; Hydrogen-Ion Concentration ; Infant, Newborn ; Kinetics ; Liver - embryology ; Liver - enzymology ; Liver - growth & development ; Pregnancy</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1972-03, Vol.139 (3), p.778-782</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-5d5c3f63ea365d271f7551b0bc38af66d085111bfab1da8094dbab1b090768b73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5023765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Messina, Anita M.</creatorcontrib><creatorcontrib>Chacko, Claramma M.</creatorcontrib><creatorcontrib>Nadler, Henry L.</creatorcontrib><title>Glucose-6-phosphate Dehydrogenase in the Developing Human Liver</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
G-6-PD was studied in human liver at various stages of development. Distinct differences were observed in specific activity, pH optimum, and thermal stability of the fetal enzyme compared to newborn and adult enzyme. In contrast, no differences were observed in Michaelis-Menten constants or electrophoretic mobility.
These studies were supported by grants from the National Institutes of Health (R.R. 05475-08 and HD 00036) and the National Foundation—March of Dimes (CRS-61). Henry L. Nadler is the Given Research Professor of Pediatrics.</description><subject>Adult</subject><subject>Drug Stability</subject><subject>Electrophoresis</subject><subject>Female</subject><subject>Fetus</subject><subject>Glucosephosphate Dehydrogenase - metabolism</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Infant, Newborn</subject><subject>Kinetics</subject><subject>Liver - embryology</subject><subject>Liver - enzymology</subject><subject>Liver - growth & development</subject><subject>Pregnancy</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9LwzAUxYMoc06_gCD0ybe4pHdJ2ieRqZsw8EWfQ9Kma0fb1KQd7NubuumjT_fPOffA_SF0S8kD0ITOCQGRilhgCikGHgM_Q1PKgIUhTc_RdDTg0XGJrrzfEUKZiPkETRiJQXA2RY-resisN5jjrrS-K1VvomdTHnJnt6ZV3kRVG_XluNyb2nZVu43WQ6PaaFPtjbtGF4Wqvbk51Rn6fH35WK7x5n31tnza4Awg6THLWQYFB6OAszwWtBCMUU10BokqOM9JwiilulCa5ioh6SLXodUkJYInWsAM3R9zO2e_BuN72VQ-M3WtWmMHLxO6WBAKJBjjozFz1ntnCtm5qlHuICmRIzX5S00GavKHWji6O6UPujH538kJU9DnR92rrZE7O7g2PPtf4jfsEXRl</recordid><startdate>197203</startdate><enddate>197203</enddate><creator>Messina, Anita M.</creator><creator>Chacko, Claramma M.</creator><creator>Nadler, Henry L.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197203</creationdate><title>Glucose-6-phosphate Dehydrogenase in the Developing Human Liver</title><author>Messina, Anita M. ; Chacko, Claramma M. ; Nadler, Henry L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-5d5c3f63ea365d271f7551b0bc38af66d085111bfab1da8094dbab1b090768b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Adult</topic><topic>Drug Stability</topic><topic>Electrophoresis</topic><topic>Female</topic><topic>Fetus</topic><topic>Glucosephosphate Dehydrogenase - metabolism</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Infant, Newborn</topic><topic>Kinetics</topic><topic>Liver - embryology</topic><topic>Liver - enzymology</topic><topic>Liver - growth & development</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Messina, Anita M.</creatorcontrib><creatorcontrib>Chacko, Claramma M.</creatorcontrib><creatorcontrib>Nadler, Henry L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Messina, Anita M.</au><au>Chacko, Claramma M.</au><au>Nadler, Henry L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucose-6-phosphate Dehydrogenase in the Developing Human Liver</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1972-03</date><risdate>1972</risdate><volume>139</volume><issue>3</issue><spage>778</spage><epage>782</epage><pages>778-782</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
G-6-PD was studied in human liver at various stages of development. Distinct differences were observed in specific activity, pH optimum, and thermal stability of the fetal enzyme compared to newborn and adult enzyme. In contrast, no differences were observed in Michaelis-Menten constants or electrophoretic mobility.
These studies were supported by grants from the National Institutes of Health (R.R. 05475-08 and HD 00036) and the National Foundation—March of Dimes (CRS-61). Henry L. Nadler is the Given Research Professor of Pediatrics.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>5023765</pmid><doi>10.3181/00379727-139-36236</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1972-03, Vol.139 (3), p.778-782 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Drug Stability Electrophoresis Female Fetus Glucosephosphate Dehydrogenase - metabolism Hot Temperature Humans Hydrogen-Ion Concentration Infant, Newborn Kinetics Liver - embryology Liver - enzymology Liver - growth & development Pregnancy |
| title | Glucose-6-phosphate Dehydrogenase in the Developing Human Liver |
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