Glucose-6-phosphate Dehydrogenase in the Developing Human Liver

Summary G-6-PD was studied in human liver at various stages of development. Distinct differences were observed in specific activity, pH optimum, and thermal stability of the fetal enzyme compared to newborn and adult enzyme. In contrast, no differences were observed in Michaelis-Menten constants or...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 1972-03, Vol.139 (3), p.778-782
Hauptverfasser:	Messina, Anita M., Chacko, Claramma M., Nadler, Henry L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Drug Stability Electrophoresis Female Fetus Glucosephosphate Dehydrogenase - metabolism Hot Temperature Humans Hydrogen-Ion Concentration Infant, Newborn Kinetics Liver - embryology Liver - enzymology Liver - growth & development Pregnancy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Summary G-6-PD was studied in human liver at various stages of development. Distinct differences were observed in specific activity, pH optimum, and thermal stability of the fetal enzyme compared to newborn and adult enzyme. In contrast, no differences were observed in Michaelis-Menten constants or electrophoretic mobility. These studies were supported by grants from the National Institutes of Health (R.R. 05475-08 and HD 00036) and the National Foundation—March of Dimes (CRS-61). Henry L. Nadler is the Given Research Professor of Pediatrics.
ISSN:	0037-9727 1535-3702 1535-3699
DOI:	10.3181/00379727-139-36236